Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice [Medical Sciences]
(World News Science)

A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2) gene has recently been identified as associated with insulin resistance in humans. To understand the cellular and molecular mechanisms by which alterations in Nat2 activity might cause insulin resistance, we examined murine ortholog Nat1 knockout (KO) mice. Nat1 KO mice... ......